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CNR Research Articles
Parkinson's
Disease
Parthenogenetic Dopamine Neurons from Primate
Embryonic Stem Cells Restore Function in
Experimental Parkinson’s Disease.
Sanchez-Pernaute R, Lee H, Patterson M, Reske-Nielsen C, Yoshizaki T, Sonntag KC, Studer L, Isacson O
Brain Advance Access published July 22, 2008
Abstract
from PubMed
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Enhanced Binding of Metabotropic Glutamate Receptor Type 5 (mGluR5)
PET Tracers in the Brain of Parkinsonian Primates.
Sanchez-Pernaute R, Wang JQ, Kuruppu D, Cao L, Tueckmantel W, Kozikowski A, Isacson O, Brownell AL
Neuroimage; 2008 Aug 1;42(1):248-51. Epub Apr 20, 2008
Abstract
from PubMed
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Nociceptin/orphanin FQ Receptor
Blockade Attenuates MPTP-induced Parkinsonism.
Viaro R, Sanchez-Pernaute R, Marti M, Trapella C, Isacson O, Morari M
Neurobiology of disease; 2008 Jun;30(3):430-8. Epub 2008 Mar 8
Abstract
from PubMed
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Fate Mapping and Lineage Analyses Demonstrate the Production of a Large Number of Striatal Neuroblasts after TGF{alpha} and Noggin Striatal Infusions into the Dopamine-depleted Striatum
De Chevigny A, Cooper O, Vinuela A, Reske-Nielsen C, Lagace DC,
Eisch AJ, Isacson O
Stem Cells; June 12, 2008
Abstract
from PubMed
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Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
Mendez I, Viñuela A, Astradsson A, Mukhida K, Hallett P, Robertson H, Tierney T, Holness R, Dagher A, Trojanowski J, Isacson O
Nature Medicine; Published online: April 6, 2008
Abstract
from PubMed
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Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli
V, Constantine-Paton M, Isacson O, Jaenisch R
Proceedings of the Natl. Academy of Sci; Published online April, 2008
Abstract
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Embryonic Stem (ES) Cell-derived Pitx3-eGFP Midbrain Dopamine Neurons Survive Enrichment by FACS and Function in an Animal Model of Parkinson's Disease
Hedlund E, Pruszak J, Lardaro T, Ludwig W, Viñuela A, Kim K, Isacson O
Stem Cells; First published online April 3, 2008
Abstract
from Stem Cells
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Recent advances in cell-based therapy for Parkinson disease
Astradsson A, Cooper O, Viñuela A, Isacson O
Neurosurg Focus; January 1, 2008 24(3-4): E6
Abstract
from HighWire
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Neuroinflammation mediated by IL-1 beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
Koprich J, Reske-Nielsen C, Mithal P, Isacson O
JNeuroinflammation; February 27, 2008; 5(1): 8
Abstract
from HighWire
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Neural precursors derived from human embryonic stem cells maintain long-term proliferation without losing the potential to differentiate into all three neural lineages, including dopaminergic neurons
Hong S, Kang UJ, Isacson O, Kim KS
J. Neurochem., Jan. 2008; 104(2):316-24. Epub Oct.
18, 2007
Abstract
from PubMed
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Influence of cell preparation and target location on the behavioral recovery
after striatal transplantation of fetal dopaminergic neurons in a primate model
of Parkinson’s disease
Redmond D, Viñuela A, Kordower JH, Isacson O
Neurobiology of Disease, Jan. 2008; 29(1):103-16. Epub Aug. 28, 2007
Abstract
from PubMed
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Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models
Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S, Isacson O
Published online in Proc. Natl. Acad. Sci. August 28, 2007
Abstract
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An Endogenous Serine/Threonine Protein Phosphatase Inhibitor, G-Substrate, Reduces Vulnerability in Models of Parkinson's Disease
Chung CY, Koprich J, Endo S, Isacson O
J. Neurosci. Aug. 1, 2007
Abstract
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In vivo evidence of D(3) dopamine receptor sensitization in parkinsonian primates and rodents with l-DOPA-induced dyskinesias
Sanchez-Pernaute R, Jenkins BG, Choi JK, Chen YC, Isacson O
Neurobiol Dis., May 2007
Abstract
from PubMed
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Markers and Methods for Cell Sorting of Human Embryonic Stem Cell-derived Neural Cell Populations
Pruszak J, Sonntag KC, Aung MH, Sanchez-Pernaute R, Isacson O
Stem Cells, June 2007
Abstract
from Stem Cells
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Selection of embryonic stem cell-derived enhanced green fluorescent protein-positive dopamine neurons using the tyrosine hydroxylase promoter is confounded by reporter gene expression in immature cell populations
Hedlund E, Pruszak J, Ferree A, Viñuela A, Hong S, Isacson O, Kim K
Stem Cells, May 2007
Abstract
from Stem Cells
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Inhibition of the dopamine
D1 receptor signaling by PSD-95
Zhang J, Viñuela A, Neely M, Hallett P, Grant S, Miller G, Isacson
O, Caron M, and Yao W
J. Biol. Chem., March 16, 2007
Abstract
from HighWire
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ES cell-derived neuroepithelial cell cultures
Karki S, Pruszak J, Isacson O, Sonntag K
JoVE, Issue 1, Dec. 2006
Link
to Video Article
Transplanted dopamine neurons
derived from primate ES cells preferentially innervate DARPP-32 striatal
progenitors within the graft
Ferrari D, Sanchez-Pernaute R, Lee H, Studer L, Isacson O
Eur. J. Neurosci. October 2006
Abstract
from PubMed
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Enhanced yield of neuroepithelial
precursors and midbrain-like dopaminergic neurons from human embryonic
stem cells using the BMP antagonist noggin
Sonntag KC, Pruszak J, Yoshizaki T, Van Arensbergen J, Sanchez-Pernaute
R, Isacson O
Stem Cells; February 2007
Abstract
from Stem Cells
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Neuroblast protuberances
in the subventricular zone of the regenerative MRL/MpJ mouse
Baker KL, Daniels SB, Lennington JB, Lardaro T, Czap A, Notti
RQ, Cooper O, Isacson O, Frasca S Jr, Conover JC
J Comp Neurol. Aug 22, 2006
Abstract
from PubMed
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A tyrosine hydroxylase-yellow
fluorescent protein knock-in reporter system labeling dopaminergic neurons
reveals potential regulatory role for the first intron of the rodent tyrosine
hydroxylase gene
Kelly BB, Hedlund E, Kim C, Ishiguro H, Isacson O, Chikaraishi
DM, Kim KS, Feng G
Published in Neuroscience on July 28, 2006
Abstract
from PubMed
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Axonal growth regulation
of fetal and ES-derived dopaminergic neurons by Netrin-1 and Slits
Lin L, Isacson O
Stem Cells; July 2006
Abstract
from Stem Cells
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Genetic selection
of sox1GFP-expressing neural precursors removes residual tumorigenic pluripotent
stem cells and attenuates tumor formation after transplantation
Chung S, Shin BS, Hedlund E, Pruszak J, Ferree A, Kang UJ, Isacson O, Kim KS
J Neurochem. June 2006
Abstract
from PubMed
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Stromal cell-derived
inducing activity, Nurr1 and signaling molecules synergistically induce
dopaminergic neurons from mouse embryonic stem cells
Kim DW, Chung S,
Hwang M, Ferree A, Tsaia HC, Park JJ, Chung S, Namc TS, Kang UJ, Isacson
O, Kim KS
Stem Cells; March 2006
Abstract
from Stem Cells
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file
Neural precursors derived
from embryonic stem cells, but not those from fetal ventral mesencephalon,
maintain the potential to differentiate into dopaminergic neurons after
expansion in vitro
Chung S, Shin BS, Hwang M, Lardaro T, Kang UJ, Isacson O, Kim
KS
Stem Cells; March 16, 2006
Abstract
from Stem Cells
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Specific microRNAs modulate
ES cell-derived neurogenesis
Krichevsky AM, Sonntag KC, Isacson O, Kosik KS
Stem Cells Vol. 24 No. 4 April 2006, pp.
857-864
Abstract
from Stem Cells
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Insights
into Parkinson's disease models and neurotoxicity using non-invasive imaging
Sanchez-Pernaute R, Brownell AL, Jenkins BG, Isacson O.
Toxicol Appl Pharmacol. 2005 Sep 1;207(2
Suppl):251-6.
Abstract
from PubMed
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pdf file
Long-term survival of dopamine neurons derived from
parthenogenetic primate embryonic stem cells (Cyno1) after transplantation
Sanchez-Pernaute R, Studer L, Ferrari D, Perrier A, Lee H, Viñuela A,
Isacson O.
Stem Cells. 2005 Jun 7
Abstract
from PubMed
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file
Cell type specific gene expression
of midbrain dopaminergic neurons reveals molecules involved in their vulnerability
and protection
Chung CY, Seo H, Sonntag KC, Brooks A, Lin L, Isacson O.
Hum. Mol. Genet. 2005; 14: 1709-1725.
Abstract
from PubMed
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Cell type analysis of functional
fetal dopamine cell suspension transplants in the striatum and substantia
nigra of patients with Parkinson's disease
Mendez I, Sanchez-Pernaute R, Cooper O, Viñuela A, Ferrari D, Björklund
L, Dagher A, and Isacson O.
Brain 2005 128(7):1498-1510
Abstract
from PubMed
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Stem cells may reshape the prospect
of Parkinson's disease therapy
Sonntag KC, Simantov R, Isacson O.
Brain Res Mol Brain Res. 2005 Mar 24;134(1):34-51.
Abstract
from PubMed
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file
Netrin-1 and slit-2 regulate and
direct neurite growth of ventral midbrain dopaminergic neurons
Lin L, Rao Y and Isacson O.
Mol Cell Neurosci. 2005 Mar;28(3):547-55.
Abstract
from PubMed
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Context-dependent neuronal differentiation
and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells
Sonntag KC, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke
F, Gilmartin J, Ding J, Hu YP, Shen MM and Isacson O
Mol Cell Neurosci. 2005 Mar;28(3):417-29.
Abstract
from PubMed
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pdf file
The homeodomain transcription factor
Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing
dopaminergic neurons
Chung S, Hedlund E, Hwang M, Kim DW, Shin BS, Hwang DY, Jung Kang U, Isacson
O, Kim KS.
Mol Cell Neurosci. 2005 Feb;28(2):241-52.
Abstract
from PubMed
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Mapping dopamine function in primates
using pharmacologic magnetic resonance imaging
Jenkins BG, Sanchez-Pernaute R, Brownell AL, Chen YI and Isacson O.
J. Neurosci., Oct 27, 2004, 24(43):9553-9560
Abstract
from PubMed
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file
Intrastriatal transforming growth
factor delivery to a model of Parkinson's disease induces proliferation
and migration of endogenous adult neural progenitor cells without differentiation
into dopaminergic neurons
Cooper, O. and Isacson, O.
J. Neurosci., Oct 13, 2004, 24(41):8924-8931
Abstract
from PubMed
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Problems and solutions for circuits
and synapses in Parkinson's disease
Isacson, O.
Neuron. 2004 Jul 22;43(2):165-8
Listing
from PubMed
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Selective COX-2 inhibition prevents
progressive dopamine neuron degeneration in a rat model of Parkinson's
disease.
Sánchez-Pernaute R, Ferree A, Cooper O, Yu M, Brownell AL and Isacson
O.
Journal of Neuroinflammation 2004, 1:6
Abstract
from PubMed
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pdf file
Temporally induced Nurr1 can induce
a non-neuronal dopaminergic cell type in embryonic stem cell differentiation.
Sonntag KC, Simantov R, Kim KS, Isacson, O.
Eur. J. Neurosci. 2004 19, 1141-1152.
Abstract
from PubMed
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Mapping of brain function after MPTP-induced
neurotoxicity in a primate Parkinson's disease model.
Brownell AL, Canales K, Chen YI, Jenkins BG, Owen C, Livni E, Yu M, Cicchetti
F, Sanchez-Pernaute R, Isacson O.
Neuroimage. 2003 Oct;20(2):1064-75.
Abstract
from PubMed
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The production and use of cells
as therapeutic agents in neurodegenerative diseases.
Isacson O.
Lancet Neurology 2003 Jul;2(7):417-24.
Abstract
from PubMed
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Orphan nuclear receptor Nurr1
directly transactivates the promoter activity of the tyrosine hydroxylase
gene in a cell-specific manner.
Kim KS, Kim CH, Hwang DY, Seo H, Chung S, Hong SJ, Lim JK, Anderson T,
Isacson O.
J Neurochem 2003 May;85(3):622-34.
Abstract
from PubMed
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Toward full restoration of synaptic
and terminal function of the dopaminergic system in Parkinson's disease
by stem cells.
Isacson O, Bjorklund LM, Schumacher JM.
Ann Neurol 2003;53(3 Suppl 1):S135-48.
Parkinson's
disease Special Annals of Neurology Issue:
Abstract
from PubMed
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Immune parameters relevant to neural
xenograft survival in the primate brain.
Cicchetti F, Fodor W, Deacon TW, Van Horne C, Rollins S, Burton W, Costantini
LC, Isacson O.
Xenotransplantation 2003 Jan;10(1):41-9.
Abstract
from PubMed
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Altered proteasomal function in sporadic
Parkinson's disease.
St P McNaught K, Belizaire R, Isacson O, Jenner P, Olanow CW.
Exp Neurol 2003 Jan;179(1):38-46.
Abstract
from PubMed
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Genetic engineering of mouse embryonic
stem cells by Nurr1 enhances differentiation and maturation into dopaminergic
neurons.
Chung, S., Sonntag, K-C., Andersson, T., Bjorklund, L.M., Park, J.-J.,
Kim, D-W., Kang, U.J., Isacson, O., Kim, K.-S.
Eur. J. Neurosci. 2002 16, 1829-1838.
Abstract
from Synergy
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Combined inhibition of apoptosis
and complement improves neural graft survival of embryonic rat and porcine
mesencephalon in the rat brain.
Cicchetti F, Costantini L, Belizaire R, Burton W, Isacson O, Fodor W.
Exp Neurol 2002; 177, 376-84
Abstract
from PubMed
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Functional Imaging of the Dopamine
System: In Vivo Evaluation of Dopamine Deficiency and Restoration
Sánchez-Pernaute R, Brownell A-L, Isacson O
Neurotoxicology 2002 vol 23, 469-478
Abstract
from PubMed
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Selective loss of 20S proteasome
alpha-subunits in the substantia nigra pars compacta in Parkinson's disease.
McNaught KS, Belizaire R, Jenner P, Olanow CW, Isacson O
Neurosci Lett 2002 Jul 5;326(3):155-8
Abstract
from PubMed
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Models of repair mechanisms for future
treatment modalities of Parkinson's disease.
Isacson O
Brain Res Bull 2002 Apr;57(6):839-46
Abstract
from PubMed
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Neuroinflammation of the nigrostriatal
pathway during progressive 6-OHDA dopamine degeneration in rats
monitored by immunohistochemistry and PET imaging.
Cicchetti F, Brownell AL, Williams K, Chen YI, Livni E and Isacson O
Eur. J. Neurosci. 2002 15, 991-998
Abstract
from PubMed
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Embryonic stem cells develop into
functional dopaminergic neurons after transplantation in a Parkinson rat
model.
Björklund L, Pernaute RS, Chung S, Andersson T, Chen IYC, McNaught
KSP, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O
Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2344-2349.
Abstract
from PubMed
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Parkinsonian Motor Deficits Are Reflected
by Proportional A9/A10 Dopamine Neuron Degeneration in the Rat.
Moore AE, Cicchetti F, Hennon J, Isacson O.
Experimental Neurology 2001 Dec;172(2):363-376
Abstract
from PubMed
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Failure of the ubiquitin-proteasome system in Parkinson's
disease.
McNaught KS, Olanow CW, Halliwell B, Isacson O, Jenner P.
Nat Rev Neurosci 2001 Aug;2(8):589-594
Abstract
from PubMed
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Cell implantation therapies for Parkinson's disease
using neural stem, transgenic or xenogeneic donor cells.
Isacson O, Costantini L, Schumacher JM, Cicchetti F, Chung S,
Kim K
Parkinsonism Relat. Disord. 2001 Jul;7(3):205-212
Abstract
from PubMed
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Immunophilin ligands can prevent progressive dopaminergic
degeneration in animal models of Parkinson's disease.
Costantini LC, Cole D, Chaturvedi P, Isacson O
Eur J Neurosci 2001 Mar;13(6):1085-92
Abstract
from PubMed
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Immunophilin ligands and GDNF enhance
neurite branching or elongation from developing dopamine neurons in culture.
Costantini LC, Isacson O
Exp Neurol 2000 Jul;164(1):60-70
Abstract
from PubMed
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Dopamine imaging markers and predictive
mathematical models for progressive degeneration in Parkinson's disease.
Brownell AL, Jenkins BG, Isacson O
Biomed Pharmacother 1999 Apr;53(3):131-40
Abstract
from PubMed
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Combined PET/MRS brain studies show
dynamic and long-term physiological changes in a primate model of Parkinson
disease.
Brownell AL, Jenkins BG, Elmaleh DR, Deacon TW, Spealman RD,
Isacson O
Nat Med 1998 Nov;4(11):1308-12
Abstract
from PubMed
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Blastula-stage stem cells can differentiate
into dopaminergic and serotonergic neurons after transplantation.
Deacon T, Dinsmore J, Costantini LC, Ratliff J, Isacson O
Exp Neurol 1998 Jan;149(1):28-41
Abstract
from PubMed
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Neural transplantation studies reveal
the brain's capacity for continuous reconstruction.
Isacson O, Deacon T
Trends Neurosci 1997 Oct;20(10):477-82
Abstract
from PubMed
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Histological evidence of fetal pig
neural cell survival after transplantation into a patient with Parkinson's
disease.
Deacon T, Schumacher J, Dinsmore J, Thomas C, Palmer P, Kott
S, Edge A, Penney D, Kassissieh S, Dempsey P, Isacson O Nat Med 1997
Mar;3(3):350-3
Abstract
from PubMed
Huntington's
Disease
Compensatory changes in the ubiquitin-proteasome system, BDNF and
mitochondrial complex II / III in YAC72 and R6/2 transgenic mice partially
model Huntington's disease (HD) patients.
Seo H, Kim W, Isacson O.
Human Molecular Genetics July 17, 2008. 10.1093/hmg/ddn211
Abstract
Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells.
Seo H, Sonntag KC, Kim W, Cattaneo E, Isacson O.
PLoS ONE February 2007
Abstract
from PubMed
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What are the long-term effects of neural grafting in patients with Huntington's disease?
Isacson O.
Nat Clin Pract Neurol. Sept 2006
Abstract
from PubMed
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Generalized brain and skin proteasome inhibition in Huntington's disease.
Hyemyung Seo, PhD, Kai-Christian Sonntag, MD, PhD, Ole Isacson,
MD, DMSc
Annals of Neurology; Sept 2004
Abstract
from PubMed
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The
production and use of cells as therapeutic agents in neurodegenerative
diseases.
Isacson O.
Lancet Neurol. 2003 Jul;2(7):417-24
Abstract
from PubMed
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Neurotrophic factors NGF and FGF-2
alter levels of huntingtin (IT15) in striatal neuronal cell cultures.
Haque NS and Isacson O
Cell Transplant 2000 Sep-Oct;9(5):623-7
Abstract
from PubMed
Transplanted fetal striatum in Huntington's
disease: phenotypic development and lack of pathology.
Freeman TB, Cicchetti F, Hauser RA, Deacon TW, Li XJ, Hersch SM, Nauert
GM, Sanberg PR, Kordower JH, Saporta S, Isacson O Proc Natl Acad Sci
U S A 2000 Dec 5;97(25):13877-82
Abstract
from PubMed
Therapeutic strategies for Huntington's
disease based on a molecular understanding of the disorder.
Haque NS, Borghesani P, Isacson O
Mol Med Today 1997 Apr;3(4):175-83
Abstract
from PubMed
Antisense gene therapy for neurodegenerative
disease?
Haque N, Isacson O
Exp Neurol 1997 Mar;144(1):139-46
Abstract
from PubMed
Gene transfer to the nigrostriatal
system by hybrid herpes simplex virus/adeno-associated virus amplicon
vectors.
Costantini LC, Jacoby DR, Wang S, Fraefel C, Breakefield
XO, Isacson O
Hum Gene Ther 1999 Oct 10;10(15):2481-94
Abstract
from PubMed
Transplanted xenogeneic neural cells
in neurodegenerative disease models exhibit remarkable axonal target specificity
and distinct growth patterns of glial and axonal fibres.
Isacson O, Deacon TW, Pakzaban P, Galpern WR, Dinsmore
J, Burns LH
Nat Med 1995 Nov;1(11):1189-94
Abstract
from PubMed
NGF attenuates 3-nitrotyrosine formation
in a 3-NP model of Huntington's disease.
Galpern WR, Matthews RT, Beal MF, Isacson O
Neuroreport 1996 Nov 4;7(15-17):2639-42
Abstract
from PubMed
Alzheimer's,
ALS and Other Neurodegenerative Diseases
Cell therapy and stem cells in animal models of motor
neuron disorders
Hedlund E, Hefferan M, Marsala M, Isacson O
European Journal of Neuroscience, Vol. 26, pp. 1721 - 37, 2007
Abstract
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Reducing Amyloid Plaque Burden via Ex Vivo Gene Delivery of an AB-Degrading Protease: A Novel Therapeutic Approach to Alzheimer Disease
Hemming M, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe D
PLoS Med. 2007 August; 4(8): e262.
Abstract
from PLoS
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pdf file
Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's
model mice.
Seo H and Isacson O
Exp Neurol. 2005 Jun;193(2):469-80.
Abstract
from PubMed
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pdf file
Region-specific cell grafting into
cervical and lumbar spinal cord in rat: a qualitative and quantitative
stereological study.
Kakinohana O, Cizkova D, Tomori Z, Hedlund E, Marsala S, Isacson
O, Marsala M.
Exp Neurol. 2004 Nov;190(1):122-32.
Abstract
from PubMed
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Estrogen alters amyloid precursor
protein as well as dendritic and cholinergic markers in a mouse model
of Down syndrome.
Granholm AC, Sanders L, Seo H, Lin L, Ford K, Isacson O.
Hippocampus. 2003;13(8):905-14.
Abstract
from PubMed
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The
production and use of cells as therapeutic agents in neurodegenerative
diseases.
Isacson O.
Lancet Neurol. 2003 Jul;2(7):417-24.
Abstract
from PubMed
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Regional alterations in amyloid precursor
protein and nerve growth factor across age in a mouse model of Down's
syndrome.
Hunter CL, Isacson O, Nelson M, Bimonte-Nelson H, Seo H, Lin L, Ford K,
Kindy MS, Granholm AC.
Neurosci Res 2003 Apr;45(4):437-45
Abstract
from PubMed
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Spatial memory testing decreases
hippocampal amyloid precursor protein in young, but not aged, female rats.
Bimonte HA, Granholm AC, Seo H, Isacson O.
Neurosci Lett 2002 Aug 2;328(1):50-4
Abstract
from PubMed
Alzheimer's disease and Down's syndrome:
roles of APP, trophic factors and ACh.
Isacson O, Seo H, Lin L, Albeck D, Granholm AC.
Trends Neurosci 2002 Feb;25(2):79-84
Abstract
from PubMed
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Cortico-hippocampal APP and NGF levels
are dynamically altered by cholinergic muscarinic antagonist or M1 agonist
treatment in normal mice.
Seo H, Ferree AW, Isacson O.
Eur J Neurosci 2002 Feb;15(3):498-506
Abstract
from PubMed
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Selective Antibody-Induced Cholinergic
Cell and Synapse Loss Produce Sustained Hippocampal and Cortical Hypometabolism
with Correlated Cognitive Deficits
Browne SE, Lin L, Mattsson A, Georgievska B, Isacson O
Experimental Neurology July 2001, Vol. 170, No. 1: 36-47
Abstract from
Ideal Library
Cognitive changes and modified processing
of amyloid precursor protein in the cortical and hippocampal system after
cholinergic synapse loss and muscarinic receptor activation.
Lin L, Georgievska B, Mattsson A, Isacson O
Proc Natl Acad Sci U S A 1999 Oct 12;96(21):12108-13
Abstract
from PubMed
Morris water maze analysis of 192-IgG-saporin-lesioned
rats and porcine cholinergic transplants to the hippocampus.
LeBlanc CJ, Deacon TW, Whatley BR, Dinsmore J, Lin L, Isacson
O
Cell Transplant 1999 Jan-Feb;8(1):131-42
Abstract
from PubMed
Pig fetal septal neurons implanted
into the hippocampus of aged or cholinergic deafferented rats grow axons
and form cross-species synapses in appropriate target regions.
Deacon T, Whatley B, LeBlanc C, Lin L, Isacson O
Cell Transplant 1999 Jan-Feb;8(1):111-29
Abstract
from PubMed
Chronic cognitive deficits and amyloid
precursor protein elevation after selective immunotoxin lesions of the
basal forebrain cholinergic system.
Lin L, LeBlanc CJ, Deacon TW, Isacson O
Neuroreport 1998 Feb 16;9(3):547-52
Abstract
from PubMed
Excitotoxic lesions of the rat entorhinal cortex.
Effects of selective neuronal damage on acquisition and retention of a
non-spatial reference memory task.
Levisohn LF, Isacson O
Brain Res 1991 Nov 15;564(2):230-44
Abstract
from PubMed
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