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  Director: Ole Isacson, M.D.


Home Up SeminarsParkinson's Huntington's Alzheimer's

Recent and Future Conferences

EPFL Life Sciences Seminar Series June 15, 2018 Website
Keystone Symposia on iPSCs: A Decade of Progress and Beyond March 25-29, 2018 Website
Society for Neuroscience in Anesthesiology and Critical Care October 19-20, 2017 Website
Oxford University Parkinson's Disease Centre December 3, 2013 Flyer
XXVIII International Pontifical Conference on Aging November 21-23, 2013 Program
Neurobiology of Disease Workshop November 8, 2013 Website
Life Science Symposium August 28-30, 2013 Website
Society of Biological Psychiatry Annual Scientific Convention May 16-18, 2013 Website


McLean Neuroscience and Center for Neuroregeneration Research Seminar Series


The Francis deMarneffe Building

The Center for Neuroregeneration Research and the McLean Neuroscience Seminar Series lectures are held on Tuesdays at 11:00 a.m. in the Francis deMarneffe Building, Room 132, McLean Hospital, Belmont, Massachusetts.

The Neuroregeneration Laboratories (NRL) Seminars are held in Mailman Research Center Room 130.

For more information, please contact Sandra Pohlman at (617) 855-3283 or


Beth Stevens, Ph.D. Boston Children’s Hospital October 3, 2017
David Priestmann, Ph.D. University of Oxford May 19, 2017
Michelle L. Hastings, Ph.D. Chicago Medical School May 9, 2017
Penny Hallett, Ph.D. McLean Hospital Neuroregeneration Institute March 21, 2017
Dennis Selkoe M.D. Brigham and Women’s Hospital March 7, 2017
Clifford Woolf, MB, BCh, Ph.D. Boston Children’s Hospital December 13, 2016
Tracey Young-Pearse, Ph.D. Brigham and Women’s Hospital June 7, 2016
Jordan Smoller, M.D., Sc.D. Massachusetts General Hospital March 24, 2015
J. Timothy Greenamyre, M.D., Ph.D. University of Pittsburgh March 4, 2014 (notice)
S. Pablo Sardi, Ph.D. Genzyme October 22, 2013(notice)
Stephen Haggarty, Ph.D. Harvard Medical School June 19, 2012 (notice)
Hongjun Song, Ph.D. Johns Hopkins University May 29, 2012 (notice)
Claudio Hetz, Ph.D. University of Chile May 17, 2012 (notice)
Giovanni Manfredi, M.D., Ph.D. Weill Medical College of Cornell University Sep. 28, 2009(notice)
Siew-Lan Ang, Ph.D. MRC National Institute for Medical Research June 9, 2008(notice)
Bernardo Sabatini, M.D., Ph.D. Harvard Medical School June 2, 2008(notice)
Clay Reid, M.D., Ph.D. Harvard Medical School March 3, 2008(notice)
Anthony A. Grace, Ph.D. University of Pittsburgh December 3, 2007(notice)
Kenneth Williams, M.D. Beth Israel Deaconess Medical Center January 12, 2007
Alberto Ascherio, M.D., Dr. PH Harvard School of Public Health April 18, 2006(notice)
Michelino Puopolo, Ph.D. Harvard Medical School March 28, 2006(notice)
Zbigniew Wszolek, M.D. Mayo Medical School January 31, 2006 (notice)
Beverly Davidson, Ph.D. University of Iowa College of Medicine January 24, 2006 (notice)
Joshua Sanes, Ph.D. Harvard University December 6, 2005 (notice)
Lorenz Studer, M.D., Ph.D. Memorial Sloan-Kettering Cancer Center October 25 , 2005 (notice)
Enza Maria Valente, M.D., Ph.D. Mendel Institute, Rome, Italy June 28, 2005 (notice)
Valina Dawson, Ph.D. Johns Hopkins School of Medicine May 3, 2005 (notice)
James Surmeier, Ph.D. Northwestern University Med. Sch. April 12, 2005 (notice)
Bernardino Ghetti, M.D. Indiana University School of Medicine January 4, 2005 (notice)
Mahendra S. Rao, M.D., Ph.D. National Institute of Aging September 14, 2004 (notice)
Robert E. Burke, M.D. Columbia University June 22, 2004 (notice)
Mark Cookson, Ph.D. National Institute on Aging, NIH April 27, 2004 (notice)
Karen K. Hsiao Ashe, M.D., Ph.D. University of Minnesota April 6, 2004 (notice)
Pullanipally Shashidharan, Ph.D. Mount Sinai School of Medicine March 23, 2004 (notice)
Roberto Malinow, M.D., Ph.D. Cold Spring Harbor Laboratory December 16, 2003 (notice)
H. Georg Kuhn, Ph.D. University of Regensburg November 18, 2003 (notice)
George Augustine, Ph.D. Duke University Medical Center April 8, 2003 (notice)  
Ryosuke Takahashi, M.D., Ph.D. RIKEN Brain Science Institute April 1, 2003 (notice)
Warren Olanow, M.D. Mt. Sinai Medical Center March 18, 2003 (notice)
David van Vactor, Ph.D. Harvard Medical School February 11, 2003
Su-Chun Zhang, M.D., Ph.D. University of Wisconsin January 14, 2003
David H. Rowitch, M.D., Ph.D. Dana-Farber Cancer Institute October 23, 2002
Cynthia A. Lemere, Ph.D. Brigham & Women’s Hospital March 5, 2002
Elena Cattaneo, Ph.D. University of Milano March 19, 2002
Mel B. Feany, M.D., Ph.D. Brigham and Women's Hospital November 27, 2001
Martin Marsala, M.D. University of California, San Diego November 20, 2001
Emanuel DiCicco-Bloom, M.D. UMDNJ-Robert Wood Johnson Med Sch October 23, 2001
Stephen Davies, Ph.D. Baylor College of Medicine October 2, 2001
Dan Lindholm, Ph.D. Uppsala University June 26, 2001
Robert Edwards, M.D. Univ. of California San Francisco April 10, 2001
Bruce Trapp, Ph.D. The Cleveland Clinic Foundation February 6, 2001
William Hickey, M.D. Dartmouth Medical School January 9, 2001
Thomas Perlmann, Ph.D. Ludwig Institute for Cancer Research December 5, 2000
Ivar Mendez, M.D., Ph.D. Dalhousie University October 24, 2000
Clive Svendsen, Ph.D.  Cambridge Center for Brain Repair September 26, 2000
Jonas Frisen, M.D., Ph.D. Karolinska Institute September 12, 2000

Neuroregeneration Lab Seminars

Ria Thomas, Ph.D. "A new role for the pluripotency factor CBX7 in human neural development" July 20, 2017
Oystein Brekk, Ph.D. "Concerning lysosomes (and α-synuclein): dopaminergic survival essentials" March 24, 2016
Elizabeth B. Moloney, Ph.D. "Axon guidance molecules and disease: presymptomatic players in neurodegeneration" Deceber 16, 2015
Valerie Joers, Ph.D. "Cardiac dysautonomia and denervation in Parkinson's disease" February 18, 2014
Joanne Clark, Ph.D. "Novel therapeutic interventions in neurodegenerative disease" February 4, 2014
Joanna Korecka-Roet, Ph.D. "Role of Repulsive Guidance Molecule A in the degneration of dopaminergic neurons in Parkinson's Disease" July 11, 2013
Emily Mangano, Ph.D. "Cytokines modulate cell death in a mouse model of Parkinson's disease" April 6, 2012
Hanneke Verstegen, Ph.D. "Cdk5-dependent phosphorylation of Synapsin I: Impact on presynaptic function" Dec. 15, 2011
Johan Jansson, Ph.D. "Acute lymphoblastic leukemia in the allogeneic environment" Aug. 26, 2011
Alexandra Magold, Ph.D. "Gamma-Secretase Dependent Gene Transcription: A New Focus of Alzheimer's Disease Research" Aug. 19, 2011
Shane Grealish, Ph.D. "New insights into cell replacement therapy in rodent models of Parkinson's disease" Aug. 4, 2011
Gaynor Smith, Ph.D. "Translation of the unilateral 6-OHDA lesion model from rat to mouse" July 15, 2011
Brigitt Schuele, M.D. "Developing a Novel model of Parkinson's disease: induced Pluripotent Stem Cells" Nov. 2, 2010
Maria Sundberg, Ph.D. "In vitro and in vivo study of embryonic and fetal stem cells: Pluripotency, Proliferation, Differentiation and Safety properties of neural grafts designed for treatment of Spinal cord injury" June 14, 2010
Haeman Jang, Ph.D. "H5N1 Influenza Virus Induces A Parkinsonian Pathology" Jan. 21, 2010
Dustin Wakeman, Ph.D. "Gene Therapy Meets Midbrain Human Neural Stem Cell Transplantation in a Primate Model for Parkinson's Disease: Modality Check In-Vivo" Oct. 28, 2009
Zinayida Shevstova, Ph.D. "Development and use of AAV-vectors for gene therapy of Parkinson's Disease" Sept. 4, 2009
Jesse McLean, Ph.D. "Peripherin Isoform Expression in ALS: Converging Concepts of Splicing, Aggregation, and Motor Neuron Degeneration" Aug. 6, 2009
Hiroko Kishikawa, Ph.D. "Diverse Roles of Angiogenin: Implications in ALS" June 4, 2009
Hara Kang, Ph.D. "CDC73 is required for self-renewal of planarian stem cells" May 13, 2009
Bikem Akten, Ph.D. "A tale of two kinases in the Drosophia circadian oscillator" June 4, 2008
Teresia Osborn, Ph.D. "Plasma gelsolin: an anti-inflammatory protein" April 15, 2008
Malu Tansey, Ph.D. "The interplay of genetics and environment in Parkinson's disease: lessons from second-hit neuroinflammation models of neurodegeneration" January 10, 2008
Pembe Hande Orzdinler, Ph.D. "Corticospinal Motor Neuron Biology: Toward Functional Repair in Motor Neuron Circuitry" December 12, 2007
Gunnar Hargus, M.D. "Transplantation of tenascin-R ­ overexpressing murine embryonic stem cells in a mouse model of Huntington’s disease" June 8, 2007
Michela Deleidi, M.D. "Analysis of subventricular zone adult neural progenitor cells in mice affected by chronic experimental autoimmune encephalomyelitis (EAE)" May 15, 2007
Alexander Klein, Ph.D. "Restorative plasticity of the dopaminergic mesotelencephalic system in an animal model for PD" February 16, 2007
Kambiz Alavian, Ph.D. "Engrailed Expression Controls Mitochondrial Stability and Erk1/2 Signaling by Regulation of P75NTR in Midbrain Dopaminergic Neurons" January 19, 2007
Jan Schwab, M.D., Ph.D. "Aspects of axon growth inhibition as target for experimental therapeutic strategies following CNS injury" March 24, 2006
Penelope Hallett, Ph.D. "Molecular Mechanisms of NMDA Glutamate Receptor Abnormalities in Parkinson's disease" March 23, 2006
Sean Kearns "Characterization of adult and embryonic stem cell proliferation, differentiation and integrations in vitro and in nigrostriatal slice cultures March 10, 2006
Shannon Mendes "Multiple B-class Ephrins and Eph receptors regulate midline axon guidance in the developing mouse forebrain" February 3, 2006
Pawel Licznerski "Lentivirus-based RNA interference in neurons" December 8, 2005
Wei-Dong Yao, Ph.D. "Molecular mechanisms mediating dopamine-glutamate interaction in the postsynaptic density: role of PSD-95 and implications in addiction" November 1, 2005
Enrique Salero "Generation of cerebellar neurons from embryonic stem cells" September 30, 2005
Frank Soldner "Identification of BAG-2 by proteome analysis as a modifier of neuronal apoptosis" July 29, 2005
Moshe Pritsker "Large-scale gain-of-function genetic screen in mouse embryonic stem cells" July 28, 2005
Arnar Astradsson, M.D. "Deep Brain Stimulation for movement disorders" July 22, 2005
Sharon Kolk, Ph.D. 'Ephective signaling': Eph/eprin cross-talk during (meso)cortical development May 20, 2005
Justin D. Boyd "Cellular Mediators of Strain-Dependent Sensitivity to MPTP in Mice" April 15, 2005
Alexandra Blak "Fgf signaling in the development of the midbrain and anterior hindbrain" April 8, 2005
Myriam Cordey "Role of protein kinase C in estrogen modulation of neuronal viability" February 11, 2005
Antoine de Chevigny "Migration and fate determination of the adult neuronal progenitor cells- implication for cell replacement therapies" January 28, 2005
Patrice D. Smith "Calpain-mediated deregulation of cyclin dependent kinase 5 (cdk5) is associated with dopaminergic cell loss in the MPTP mouse model of Parkinson's disease" January 21, 2005
James Koprich "Consequences and Potential Mechanisms of Prenatal MDMA Exposure on Neurodevelopment" December 17, 2004
Takahito Yoshizaki, M.D., Ph.D. "Generation of dopaminergic neurons from ES cells, and Transplantation to rat models of Parkinson's disease” June 25, 2004
Petr Dvorak, Ph.D. "Deriving new human ES cell lines" June 10, 2004
Zhigang He, Ph.D.
"Molecular mechanisms of axon degeneration and regeneration"
April 8, 2004
Mee-Ohk Kim, M.D.
"CD45-mediated inhibition of HIV-1 Nef signaling in
human microglia: mechanisms and implications for
AIDS dementia"
January 21, 2004
Daniela Ferrari
"New locations of neural progenitors in the adult brain"
November 15, 2003
Haruhisa Inoue, M.D., Ph.D.
"Differential roles of caspases in the clinical course
of ALS-mouse model"
July 16, 2003
Angel Viñuela, Ph.D.
"Some anatomical aspects on the transmission of
forelimb somatosensory representation in Macaque"
May 23, 2003
Nicole Roy, Ph.D.
"Investigating the development of the caudal nervous system in
vertebrates using zebrafish as a model." (NRL)
April 25, 2003
Laura Korhonen, Ph.D.
“X chromosome-linked inhibitor of apoptosis protein
(XIAP) in neuronal cell death and survival”
November 8, 2002
Stefano Gustincich, Ph.D.
“Confronting complexity: dopaminergic neurons of the mouse retina”
August 8, 2002
Eva Hedlund, Ph.D.
"Search for Hox10 downstream targets: genes involved
in motor neuron generation and outgrowth"
May 3, 2002
Rosario S-Pernaute, M.D., Ph.D.
"Reduced hippocampal neurogenesis in adult transgenic
mice with chronic astrocytic production of interleukin-6" (NRL)
April 4, 2002
Kai Sonntag, M.D., Ph.D.
"Cell Proliferation Without Neurogenesis in Adult Primate Neocortex" (NRL)
February 28, 2002
Dong-Wook Kim, Ph.D.
"Sonic Hedgehog Facilitates Dopamine Differetiation in
the Presence of a Mesencephalic Glial Cell Line" (MNL)
January 30, 2002
Chee Yeun Chung
"Glutamate Excitotoxicity Causes Rapid Degradation of
the Neuronal K-Cl Cotransporter (KCC2) via a Calcium-
activated Neutral Protease" (NRL)
January 25, 2002
Sangmi Chung, Ph.D.
"Generation of Dopaminergic Neurons in the Adult Brain
from Mesencephalic Precursor Cells Labeled with a nestin-
GFP Transgene" (MNL)
January 16, 2002
Kai Sonntag, M.D., Ph.D.
"In viteo differentiation of transplantable neural precursors
from human embryonic stem cells" (MNL)
December 12, 2001
Carine Cleren
"Effects of pharmacological agents on the nigro-striatal
dopaminergic neurotoxicity induced by MPP+ and 6-OHDA" (NRL)
November 20, 2001
Jason Emsley
"Revelations about the Genesis and Exodus of Neural Stem Cells" (NRL)
October 18, 2001
Stefan Haas
"Transplantation of immortalized neural progenitor cells in
hemi-parkinsonian rats" (NRL)
September 21, 2001
Marina Emborg, M.D., Ph.D.
"Primate models in pre clinical studies of Parkinson's and
Huntington's disease" (NRL)
June 29, 2001
Raja Kittappa, Ph.D.
"Gene expression and the emergence of stem cells” (NRL)
April 26, 2001
Antonella Consiglio, Ph.D.
"In vivo gene therapy of metachromatic leucodystrophy
by lentiviral vector" (NRL)
April 12, 2001
Sangmi Chung, Ph.D.
"Neurogenin Promotes Neurogenesis and Inhibits Glial
Differentiation by Independent Mechanisms" (MNL)
March 28, 2001




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