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Director: Prof. Ole Isacson, Biography and Research
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IN THE NEWS AND MEDIA (click here for more news)

FRONTLINE: A Report on Parkinson's Disease
Update on PBS: June, 2012

Neuroregeneration Institute Intensifies Quest for New Parkinson's Treatments

NIH Grant Awarded for PDiPS Cell Consortium
PDiPS Consortium Abstract PDF
PDiPS Consortium website

Neuroregeneration Institute lands 6 new Michael J. Fox Foundation competitive research awards
Click here for the MJFF website announcement and specific studies underway

Drs. Ole Isacson and Penny Hallett receive new funding from CHDI for Huntington's disease research
CHDI Foundation website

Dr. Ole Isacson receives new federal grant for innovative ALS work
ALS Abstract PDF


Hallett Cover 2012


Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits.
Neurobiol Dis,Apr. 19, 2012 •47:258-67.











Viral and Inflammatory Triggers of Neurodegenerative Diseases.
Sci Transl Med, Feb 15, 2012 • 4:121-3.

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Using stem cells and iPS cells to discover new treatments for Parkinson's disease.
Parkinsonism Relat Disord, Jan 18, 2012. Suppl 1:S14-6.

Abstract fromPubMed
PDF File

Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression.
Mol Cell Neurosci, Dec 6, 2011 [Epub ahead of print]

Abstract from PubMed

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Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons.
PLoS One, Published online May 31, 2011 • 6(5): e19926.
Abstract from PubMed
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Development of histocompatible primate induced pluripotent stem cells for neural transplantation.
Stem Cells, May 23, 2011 • 29(7):1052-63.
Abstract from PubMed
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Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease.
The Journal of Neurology,
August, 2011 • 258(8):1393-405.
Abstract from PubMed
PDF File

The Toll-Like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.
The Journal of Neuroscience, December 1, 2010 • 30(48): 16091- 101.
Abstract from JNeurosci
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Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Proceedings of the National Academy of Sciences, September 2010 • 107: 15921- 26.
Abstract from PNAS
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Last modified: Wednesday, June 22, 2011