IN
THE NEWS AND MEDIA
Harvard Stem Cell Institute Monthly Update
December 2009
Highlights: New Stem Cell Findings At the Center for Neuroregeneration
Research
HSCI Highlights Stem Cell Sorting Work at the Neuroregeneration Lab
Research Newsletter; October 2009
Article Link
NINDS GO Grant funding awarded for PDiPS Cell Line Research Consortium
Article Link
Interview with Dr. Isacson
Harvard NeuroDiscovery Center
Cozzarelli Prize Awarded
The Cozzarelli Prize recognizing recently published PNAS papers of outstanding
scientific excellence and originality has been awarded to Wernig et al.
2008. This article is a shared collaborative work between the Harvard/McLean
(Dr Isacson's lab) and MIT (Dr Jaenisch's lab). This is the first paper
to show induction of stem cells from skin cells, then conversion to dopaminergic
cells and successful functional testing in animal models of Parkinson’s
disease.
Press Release from Eurekalert
Wernig
et al. 2008 PDF File
FRONTLINE: A Report on Parkinson's
Disease
On
PBS: Feb. 3, 2009
View video
highlights and full program on-line
Scientists create first personalized stem cells
into dopamine neurons for Parkinson's disease
Article from Southcoasttoday.com
PD iPS
cell to DA neurons CELL.pdf
Summit on Stem Cell Research and New
Clinical Trials
Brain Repair Centre/Center for
Neuroregeneration Research 2008
Press Release and Photo
Reprogrammed adult skin cells treat Parkinson's disease in animal model
HarvardScience Online; April 10, 2008
Article
Link
Stem Cells from Skin Treat
Brain Disease in Rats
Reuters Online; April 7, 2008
Article
Link
Parkinson's Brain Cell Transplants
Last for Years
Reuters Online; April 6, 2008
Article
Link
March/April 2008 Neurosurgical
Focus Interview
Ole Isacson and Nathan Selden; Stem Cell
& Nervous System Therapeutics
Listen to the Interview:
Or Download to iTunes (Mac users control-click on link, PC users right-click)
Partnership is a Real No-Brainer;
Dal-Harvard to Work Together on Brain Repair
The Chronicle Herald; February 21, 2008
Halifax Chronicle Herald, Feb. 21, 2008
Metro Newspaper, Feb. 21, 2008
Press Release
RECENT
RESEARCH ARTICLES
Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway.
Cell Stem Cell, Dec. 4, 2009 • 5(6): 646- 58.
Abstract
from PubMed
PDF File
Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.
Proceedings of the National Academy of Sciences,
Dec. 10, 2009 • 106: 22474- 79.
Abstract
PDF File
CD15, CD24 and CD29 define
a surface biomarker code for neural lineage differentiation of stem cells.
Stem Cells, Sep 1 2009 • [Epub ahead of print].
Abstract
from PubMed
PDF File
Lack of functional relevance
of isolated cell damage in transplants of Parkinson’s disease patients.
Journal of Neurology, August 27, 2009 • 256 (Suppl 3): S310- S316.
Abstract
from SpringerLink
PDF File
No evidence for disease-like
processes in fetal transplants.
Proceedings of the National Academy of Sciences, Sep 2009 • 10.1073/pnas.0908169106.
Abstract
from HighWire
PDF File
The blood-brain barrier is
intact after levodopa-induced dyskinesias in parkinsonian primates--evidence
from in vivo neuroimaging studies.
Neurobiol Dis., Sep 2009 • 35(3): 348- 51.
Abstract
from PubMed
PDF File
Dynamic changes in presynaptic
and axonal transport proteins combined with striatal neuroinflammation
precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.
The Journal of Neuroscience, March 18, 2009 • 29(11): 3365- 73.
Abstract
from PubMed
PDF File
PSD-95 Uncouples DopamineGlutamate Interaction in the D1/PSD-95/NMDA
Receptor Complex.
The Journal of Neuroscience, March 4, 2009 • 29(9): 2948 - 60.
Abstract
from PubMed
PDF File
Parkinson’s Disease Patient-Derived
Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors.
Cell 136, 964- 977, March 6, 2009.
Abstract
from PubMed
PDF File
Axon guidance and synaptic
maintenance: preclinical markers for neurodegenerative disease and therapeutics.
Trends in Neuroscience; January 21, 2009.
Abstract
from PubMed
PDF File
Implanted reuptake-deficient
or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without
OFF-dyskinesias in a rat model of Parkinson's disease.
Brain; published on-line Nov. 6, 2008.
Abstract
from Brain
PDF File
Compensatory changes in the
ubiquitin-proteasome system, BDNF and mitochondrial complex II / III in
YAC72 and R6/2 transgenic mice partially model Huntington's disease (HD)
patients.
Human Molecular Genetics; published online: July 17, 2008.
Abstract
from Oxford Journals
PDF File
Fate Mapping and Lineage Analyses
Demonstrate the Production of a Large Number of Striatal Neuroblasts after
TGF{alpha} and Noggin Striatal Infusions into the Dopamine-depleted Striatum.
Stem Cells; publ. online: June 12, 2008.
Abstract
from PubMed
PDF File
Dopamine neurons implanted
into people with Parkinson's disease survive without pathology for 14
years
Nature Medicine; publ. online: April 6, 2008.
Abstract
from PubMed
PDF File
Neurons derived from reprogrammed
fibroblasts functionally integrate into the fetal brain and improve symptoms
of rats with Parkinson's disease
Proceedings of the National Academy of Sciences; Published online:
April, 2008.
Abstract
from HighWire
PDF File
Embryonic Stem (ES) Cell-derived
Pitx3-eGFP Midbrain Dopamine Neurons Survive Enrichment by FACS and Function
in an Animal Model of Parkinson's Disease
Stem Cells; Epub April 3, 2008.
Abstract
from PubMed
PDF File
Recent advances in cell-based
therapy for Parkinson disease
Neurosurg Focus 2008 24(3-4): E6.
Abstract
from PubMed
PDF File
Neuroinflammation mediated
by IL-1 beta increases susceptibility of dopamine neurons to degeneration
in an animal model of Parkinson's disease
J Neuroinflammation; February 27, 2008; 5(1): 8.
Abstract
from HighWire
PDF File
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