NRI Prospectus

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IN THE NEWS AND MEDIA (click here for more news)

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age
Link to article on Nature.com

Researchers find that lipid accumulation in the brain may be an early sign of Parkinson's disease
Link to press release on EurekAlert!
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How anti-sense treatment for Huntington's disease started at the Neuroregeneration Laboratories | Nature
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Cell therapy from iPSC works in Parkinson's preclinical models confirmed | Alzforum
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Health and Medicine: A new era in Parkinson's disease treatments
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Engelender and Isacson suggest new theory for how Parkinson's disease develops - ScienceDaily
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Fighting Parkinson's in the Lab
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Gaucher and Parkinson's Recent Discoveries and Future Directions
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NPR Interviews Dr. Isacson about Mohammed Ali's fight with Parkinson's disease
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National Stem Cell Foundation and Michael J. Fox Foundation Partner to Support Parkinson's Cell Replacement Therapy
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MJFF Parkinson podcast with Dave Iverson and Ole Isacson 2016: The stem cells basics
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Ole Isacson Lecture on Parkinson's disease in a Dish: Induced Pluripotent Stem Cell Models of Disease SFN Neurobiology of Disease Workshop graduate course
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Lysosomes to combat Parkinson's diseases
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WMIF 2015 | Regeneration, Cell Therapy, and Neurocare: Products? Delivery?
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New data demonstrate for the first time that an age-dependent reduction in glucocerebrosidase activity may lower the threshold for developing Parkinson's disease
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Dr. Ivar Mendez and Dr. Ole Isacson show cell transplantation brain surgery for Parkinson's disease
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Harvard Gazette reports on Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
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RECENT RESEARCH ARTICLES FROM NEUROREGENERATION INSTITUTE (click here for full list of publications)

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress.
Moloney EB, Moskites A, Ferrari EJ, Isacson O, Hallett PJ.
Neurobiol Dis., 2018 Aug;120:1-11. doi: 10.1016/j.nbd.2018.08.013.
Abstract from PubMed
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Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain
Hallett et al.
Neurobiol Aging, 2018 • Mar;67:189-200 doi:10.1016/j.neurobiolaging.2018.02.028
Abstract from PubMed
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Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression.
Obsorn TM, Beagan J, Isacson O
Neurobiol Dis., 2018 Feb;110:218-230. doi: 10.1016/j.nbd.2017.11.002.
Abstract from PubMed
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Integrated Molecular Landscape of Parkinson's Disease
Kiemann et al.
npj Parkinson's Disease, 2017 • Apr;3(14), doi:10.1038/s41531-017-0015-3.
Link to Article
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The Threshold Theory for Parkinson's Disease.
Engelender S. Isacson O.
Trends Neurosci., 2017 • Jan;40(1): 4-14, doi: 10.1016/j.tins.2016.10.008.
Abstract from PubMed
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Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.
Smith et al.
Mol Neurobiol, 2016 • Oct;53(8):5161-77 doi: 10.1007/s12035-015-9435-4
Abstract from PubMed
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In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells.
Korecka et al.
Mol Cell Neurosci, 2016 • June;73:3-12, doi: 10.1016/j.mcn.2015.12.004
Abstract from PubMed
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Glucocerebrosidase gene therapy prevents a-synucleinopathy of midbrain dopamine neurons.
Rocha et al.
Neurobiol Dis, 2015 • Sept. 25, 2015, doi: 10.1016/j.nbd.2015.09.009
Abstract from PubMed
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Progressive decline of glucocerebrosidase in aging and Parkinson's disease.
Rocha et al. 
Ann Clin Transl Neurol, 2015 • 23(6), Apr. 2, 2015, doi: 10.1002/acn3.177
Abstract from PubMed
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Sustained Systemic Glucocerebrosidase Inhibition Induces Brain a-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.
Rocha et al. 
Antioxidants & Redox Signaling, 2015 • 23(6), doi: 10.1089/ars.2015.6307
Abstract from PubMed
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A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).
Smith et al.
PLoS One, 2015 • 10(3), Mar. 27, 2015, doi: 10.1371/journal.pone.0121072
Abstract from PubMed
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Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
Cell Stem Cell, 2015 • 16, 269-274
Abstract
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Long-term health of dopaminergic neuron transplants in Parkinson's disease patients
Cell Reports, 2014, 7:1755-61, doi:10.1016/j.celrep.2014.05.027
Abstract
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Progressive axonal transport and synaptic protein changes correlate with behavioral and neurpathological abnormalities in the heterozygous Q175KI mouse model of Huntington's disease
Human Molecular Genetics, April 30, 2014, doi: 10.1093/hmg/ddu166
Abstract
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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
Neurobiology of Disease, 2014 • 62:381-386
Abstract
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Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
Science Transl Med, July 4, 2012 • 4:52-64
Abstract
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Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits.
Neurobiol Dis,Apr. 19, 2012 •47:258-67.
Abstract
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Viral and Inflammatory Triggers of Neurodegenerative Diseases.
Science Transl Med, Feb 15, 2012 • 4:121-3.
Abstract
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