Parkinson's Disease Program Huntington's Disease Program Alzheimer's Disease Project Amyotrophic Lateral Sclerosis

Research Articles In the News Job Listings & Positions

McLean/Harvard Udall Res Centers of Excellence Seminar Series   Cell Transplant Society 2009- 9th Intl. Conf AD/PD 2009   18th Federation of Neurology World Congress on Parkinson's Disease and Related Disorders, Dec. 13-16, 2009 - CMT Conferences

IN THE NEWS AND MEDIA

Cozzarelli Prize Awarded
The Cozzarelli Prize recognizing recently published PNAS papers of outstanding scientific excellence and originality has been awarded to Wernig et al. 2008. This article is a shared collaborative work between the Harvard/McLean (Dr Isacson's lab) and MIT (Dr Jaenisch's lab). This is the first paper to show induction of stem cells from skin cells, then conversion to dopaminergic cells and successful functional testing in animal models of Parkinson’s disease.
Press Release from Eurekalert
Wernig et al. 2008 PDF File

FRONTLINE: A Report on Parkinson's Disease
On PBS: Feb. 3, 2009
View video highlights and full program on-line

Scientists create first personalized stem cells into dopamine neurons for Parkinson's disease
Article from Southcoasttoday.com
PD iPS cell to DA neurons CELL.pdf

Summit on Stem Cell Research and New Clinical Trials
Brain Repair Centre/Center for Neuroregeneration Research 2008
Press Release and Photo

Reprogrammed adult skin cells treat Parkinson's disease in animal model
HarvardScience Online; April 10, 2008
Article Link

Stem Cells from Skin Treat Brain Disease in Rats
Reuters Online; April 7, 2008
Article Link

Parkinson's Brain Cell Transplants Last for Years
Reuters Online; April 6, 2008
Article Link

March/April 2008 Neurosurgical Focus Interview
Ole Isacson and Nathan Selden; Stem Cell & Nervous System Therapeutics
Listen to the Interview:
Or Download to iTunes (Mac users control-click on link, PC users right-click)

Partnership is a Real No-Brainer; Dal-Harvard to Work Together on Brain Repair
The Chronicle Herald; February 21, 2008
Halifax Chronicle Herald, Feb. 21, 2008
Metro Newspaper, Feb. 21, 2008
Press Release

RECENT RESEARCH ARTICLES

Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.
The Journal of Neuroscience, March 18, 2009 • 29(11): 3365- 73.
Abstract from PubMed
PDF File

PSD-95 Uncouples Dopamine­Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex.
The Journal of Neuroscience, March 4, 2009 • 29(9): 2948 - 60.
Abstract from PubMed
PDF File

Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors.
Cell 136, 964- 977, March 6, 2009.
Abstract from PubMed
PDF File

Axon guidance and synaptic maintenance: preclinical markers for neurodegenerative disease and therapeutics.
Trends in Neuroscience; January 21, 2009.
Abstract from PubMed
PDF File

Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.
Brain; published on-line Nov. 6, 2008.
Abstract from Brain
PDF File

Compensatory changes in the ubiquitin-proteasome system, BDNF and mitochondrial complex II / III in YAC72 and R6/2 transgenic mice partially model Huntington's disease (HD) patients.
Human Molecular Genetics; published online: July 17, 2008.
Abstract from Oxford Journals
PDF File

Fate Mapping and Lineage Analyses Demonstrate the Production of a Large Number of Striatal Neuroblasts after TGF{alpha} and Noggin Striatal Infusions into the Dopamine-depleted Striatum.
Stem Cells; publ. online: June 12, 2008.
Abstract from PubMed
PDF File

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
Nature Medicine; publ. online: April 6, 2008.
Abstract from PubMed
PDF File

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
Proceedings of the National Academy of Sciences; Published online: April, 2008.
Abstract from HighWire
PDF File

Embryonic Stem (ES) Cell-derived Pitx3-eGFP Midbrain Dopamine Neurons Survive Enrichment by FACS and Function in an Animal Model of Parkinson's Disease
Stem Cells; Epub April 3, 2008.
Abstract from PubMed
PDF File

Recent advances in cell-based therapy for Parkinson disease
Neurosurg Focus 2008 24(3-4): E6.
Abstract from PubMed
PDF File

Neuroinflammation mediated by IL-1 beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
J Neuroinflammation; February 27, 2008; 5(1): 8.
Abstract from HighWire
PDF File

Mailman Research Center