NPR Interviews Dr. Isacson about Mohammed Ali's fight with Parkinson's disease Click here to listen
National Stem Cell Foundation and Michael J. Fox Foundation Partner to Support Parkinson's Cell Replacement Therapy Click here to view article
MJFF Parkinson podcast with Dave Iverson and Ole Isacson 2016: The stem cells basics Click here for podcast
Ole Isacson Lecture on Parkinson's disease in a Dish: Induced Pluripotent Stem Cell Models of Disease SFN Neurobiology of Disease Workshop graduate course Click here for video
WMIF 2015 | Regeneration, Cell Therapy, and Neurocare: Products? Delivery? Click here for video
New data demonstrate for the first time that an age-dependent reduction in glucocerebrosidase activity may lower the threshold for developing Parkinson's disease Link to article PDF File
Dr. Ivar Mendez and Dr. Ole Isacson show cell transplantation brain surgery for Parkinson's disease Click here for video
Harvard Gazette reports on Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease Click here to view article
Neurite Collapse and altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation. Korecka JA, Talbot S, Osborn TM, de Leeuw SM, Levy SA, Ferrari EJ, Moskites A, Atkinson E, Jodelka FM, Hinrich AJ, Hastings ML, Woolf CJ, Hallett PJ, Isacson O. Stem Cell Reports., 2019 Jan;12:29-41. doi: 10.1016/j.stemcr.2018.11.021. Abstract from PubMed PDF File
Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age. Brekk OR, Moskites A, Isacson O, Hallett PJ. Scientific Reports., 2018 Oct;8:15207. doi: 10.1038/s41598-018-33474-z. Abstract from PubMed PDF File
The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress. Moloney EB, Moskites A, Ferrari EJ, Isacson O, Hallett PJ. Neurobiol Dis., 2018 Aug;120:1-11. doi: 10.1016/j.nbd.2018.08.013. Abstract from PubMed PDF File
Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain Hallett et al. Neurobiol Aging, 2018 • Mar;67:189-200 doi:10.1016/j.neurobiolaging.2018.02.028 Abstract from PubMed PDF File
Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression. Obsorn TM, Beagan J, Isacson O Neurobiol Dis., 2018 Feb;110:218-230. doi: 10.1016/j.nbd.2017.11.002. Abstract from PubMed PDF File
Integrated Molecular Landscape of Parkinson's Disease Kiemann et al. npj Parkinson's Disease, 2017 • Apr;3(14), doi:10.1038/s41531-017-0015-3. Link to Article PDF File
The Threshold Theory for Parkinson's Disease. Engelender S. Isacson O. Trends Neurosci., 2017 • Jan;40(1): 4-14, doi: 10.1016/j.tins.2016.10.008. Abstract from PubMed PDF File
Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.
Smith et al. Mol Neurobiol, 2016 • Oct;53(8):5161-77 doi: 10.1007/s12035-015-9435-4 Abstract from PubMed PDF File
In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells. Korecka et al. Mol Cell Neurosci, 2016 • June;73:3-12, doi: 10.1016/j.mcn.2015.12.004 Abstract from PubMed PDF File
Glucocerebrosidase gene therapy prevents a-synucleinopathy of midbrain dopamine neurons.
Rocha et al. Neurobiol Dis, 2015 • Sept. 25, 2015, doi: 10.1016/j.nbd.2015.09.009 Abstract from PubMed PDF File
Progressive decline of glucocerebrosidase in aging and Parkinson's disease.
Rocha et al. Ann Clin Transl Neurol, 2015 •23(6), Apr. 2, 2015, doi: 10.1002/acn3.177 Abstract from PubMed PDF File
Sustained Systemic Glucocerebrosidase Inhibition Induces Brain a-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.
Rocha et al. Antioxidants & Redox Signaling, 2015 • 23(6), doi: 10.1089/ars.2015.6307 Abstract from PubMed PDF File
A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).
Smith et al. PLoS One, 2015 • 10(3), Mar. 27, 2015, doi: 10.1371/journal.pone.0121072 Abstract from PubMed PDF File
Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease Cell Stem Cell, 2015 • 16, 269-274 Abstract PDF File
Long-term health of dopaminergic neuron transplants in Parkinson's disease patients Cell Reports, 2014, 7:1755-61, doi:10.1016/j.celrep.2014.05.027 Abstract PDF File
Progressive axonal transport and synaptic protein changes correlate with behavioral and neurpathological abnormalities in the heterozygous Q175KI mouse model of Huntington's disease Human Molecular Genetics, April 30, 2014, doi: 10.1093/hmg/ddu166 Abstract PDF File
LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction Neurobiology of Disease, 2014 • 62:381-386 Abstract PDF File
Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease Science Transl Med, July 4, 2012 • 4:52-64 Abstract PDF File
Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits. Neurobiol Dis,Apr. 19, 2012 •47:258-67. Abstract PDF File
Viral and Inflammatory Triggers of Neurodegenerative Diseases. Science Transl Med, Feb 15, 2012 • 4:121-3. Abstract PDF File