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NEUROREGENERATION INSTITUTE
Director: Prof. Ole Isacson, Biography and Research
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IN THE NEWS AND MEDIA (click here for more news)

Lysosomes to combat Parkinson's disease
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Neuroscience Regenerative Medicine Changing Healthcare: Most Innovative
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New data demonstrate for the first time that an age-dependent reduction in glucocerebrosidase activity may lower the threshold for developing Parkinson's disease
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Harvard Gazette reports on Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
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Nature Biotechnology reviews the use of iPSCs for drug discovery and modeling of familial Parkinson's disease in cell culture
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Long-term survival of dopamine neurons in patients: Encouraging news for future stem-cell based dopamine neuron transplants
BBC Sponsored Audio Link for Interview with Dr. Isacson
AlzForum Article
International News Articles

Molecular and Cellular Neuroscience (MCN), Ole Isacson, Editor in Chief
View Table of Contents for the latest issue of Molecular and Cellular Neuroscience

MCN Special Issue: Mitochondrial function and dysfunction in neurodegeneration, edited by Hibiki Kawamata, Giovanni Manfredi and Marilena D'Aurelio
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RECENT RESEARCH ARTICLES FROM NEUROREGENERATION INSTITUTE (click here for full list of publications)

Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
Cell Stem Cell, 2015 • 16, 269-274

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Progressive decline of glucocerebrosidase in aging and Parkinson's disease
Annals of Clinical and Translational Neurology, 2015, Apr2(4):433-8, doi: 10.1002/acn3.177

Abstract
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Long-term health of dopaminergic neuron transplants in Parkinson's disease patients
Cell Reports, 2014, 7:1755-61, doi:10.1016/j.celrep.2014.05.027

Abstract
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Progressive axonal transport and synaptic protein changes correlate with behavioral and neurpathological abnormalities in the heterozygous Q175KI mouse model of Huntington's disease
Human Molecular Genetics, April 30, 2014, doi: 10.1093/hmg/ddu166

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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
Neurobiology of Disease, 2014 • 62:381-386

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Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
Science Transl Med, July 4, 2012 • 4:52-64

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Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits.
Neurobiol Dis,Apr. 19, 2012 •47:258-67.

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Viral and Inflammatory Triggers of Neurodegenerative Diseases.
Science Transl Med, Feb 15, 2012 • 4:121-3.

Abstract
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Using stem cells and iPS cells to discover new treatments for Parkinson's disease.
Parkinsonism Relat Disord, Jan 18, 2012. Suppl 1:S14-6.

Abstract fromPubMed
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Transcript expression levels of full-length alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression.
Mol Cell Neurosci, 2012 • 49:230-239

Abstract from PubMed

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Oct4-induced reprogramming is required for adult brain neural stem cell differentiation into midbrain dopaminergic neurons.
PLoS One, Published online May 31, 2011 • 6(5): e19926.
Abstract from PubMed
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Development of histocompatible primate induced pluripotent stem cells for neural transplantation.
Stem Cells, May 23, 2011 • 29(7):1052-63.
Abstract from PubMed
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Functions of the nigrostriatal dopaminergic synapse and the use of neurotransplantation in Parkinson's disease.
The Journal of Neurology,
August, 2011 • 258(8):1393-405.
Abstract from PubMed
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The Toll-Like receptor-3 agonist polyinosinic:polycytidylic acid triggers nigrostriatal dopaminergic degeneration.
The Journal of Neuroscience, December 1, 2010 • 30(48): 16091- 101.
Abstract from JNeurosci
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Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
Proceedings of the National Academy of Sciences, September 2010 • 107: 15921- 26.
Abstract from PNAS
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