Researchers find that lipid accumulation in the brain may be an early sign of Parkinson's disease
Link to press release on EurekAlert!
Link to article

How anti-sense treatment for Huntington's disease started at the Neuroregeneration Laboratories | Nature
Link to article

Cell therapy from iPSC works in Parkinson's preclinical models confirmed | Alzforum
Click here to view article

Health and Medicine: A new era in Parkinson's disease treatments
Click here to view article

Engelender and Isacson suggest new theory for how Parkinson's disease develops - ScienceDaily
Link to article
PDF File

Fighting Parkinson's in the Lab
Click here to view article

Gaucher and Parkinson's Recent Discoveries and Future Directions
Click here to view article

NPR Interviews Dr. Isacson about Mohammed Ali's fight with Parkinson's disease
Click here to listen

National Stem Cell Foundation and Michael J. Fox Foundation Partner to Support Parkinson's Cell Replacement Therapy
Click here to view article

MJFF Parkinson podcast with Dave Iverson and Ole Isacson 2016: The stem cells basics
Click here for podcast

Ole Isacson Lecture on Parkinson's disease in a Dish: Induced Pluripotent Stem Cell Models of Disease SFN Neurobiology of Disease Workshop graduate course
Click here for video

Lysosomes to combat Parkinson's diseases
Click here to view article

WMIF 2015 | Regeneration, Cell Therapy, and Neurocare: Products? Delivery?
Click here for video

New data demonstrate for the first time that an age-dependent reduction in glucocerebrosidase activity may lower the threshold for developing Parkinson's disease
Link to article
PDF File

Dr. Ivar Mendez and Dr. Ole Isacson show cell transplantation brain surgery for Parkinson's disease
Click here for video

Harvard Gazette reports on Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
Click here to view article

RECENT RESEARCH ARTICLES FROM NEUROREGENERATION INSTITUTE (click here for full list of publications)

Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease. Hallett PJ, Engelender S, Isacson O. J Neuroinflammation. 2019 Jul 22;16(1):153. doi: 10.1186/s12974-019-1532-2.
Abstract from PubMed
PDF File

Neurite Collapse and altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation.
Korecka JA, Talbot S, Osborn TM, de Leeuw SM, Levy SA, Ferrari EJ, Moskites A, Atkinson E, Jodelka FM, Hinrich AJ, Hastings ML, Woolf CJ, Hallett PJ, Isacson O.
Stem Cell Reports., 2019 Jan;12:29-41. doi: 10.1016/j.stemcr.2018.11.021.
Abstract from PubMed
PDF File

Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age.
Brekk OR, Moskites A, Isacson O, Hallett PJ.
Scientific Reports., 2018 Oct;8:15207. doi: 10.1038/s41598-018-33474-z.
Abstract from PubMed
PDF File

The glycoprotein GPNMB is selectively elevated in the substantia nigra of Parkinson's disease patients and increases after lysosomal stress.
Moloney EB, Moskites A, Ferrari EJ, Isacson O, Hallett PJ.
Neurobiol Dis., 2018 Aug;120:1-11. doi: 10.1016/j.nbd.2018.08.013.
Abstract from PubMed
PDF File

Glycosphingolipid levels and glucocerebrosidase activity are altered in normal aging of the mouse brain
Hallett et al.
Neurobiol Aging, 2018 • Mar;67:189-200 doi:10.1016/j.neurobiolaging.2018.02.028
Abstract from PubMed
PDF File

Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression.
Obsorn TM, Beagan J, Isacson O
Neurobiol Dis., 2018 Feb;110:218-230. doi: 10.1016/j.nbd.2017.11.002.
Abstract from PubMed
PDF File

Integrated Molecular Landscape of Parkinson's Disease
Kiemann et al.
npj Parkinson's Disease, 2017 • Apr;3(14), doi:10.1038/s41531-017-0015-3.
Link to Article
PDF File

The Threshold Theory for Parkinson's Disease.
Engelender S. Isacson O.
Trends Neurosci., 2017 • Jan;40(1): 4-14, doi: 10.1016/j.tins.2016.10.008.
Abstract from PubMed
PDF File

Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.
Smith et al.
Mol Neurobiol, 2016 • Oct;53(8):5161-77 doi: 10.1007/s12035-015-9435-4
Abstract from PubMed
PDF File

In vivo modeling of neuronal function, axonal impairment and connectivity in neurodegenerative and neuropsychiatric disorders using induced pluripotent stem cells.
Korecka et al.
Mol Cell Neurosci, 2016 • June;73:3-12, doi: 10.1016/j.mcn.2015.12.004
Abstract from PubMed
PDF File

Glucocerebrosidase gene therapy prevents a-synucleinopathy of midbrain dopamine neurons.
Rocha et al.
Neurobiol Dis, 2015 • Sept. 25, 2015, doi: 10.1016/j.nbd.2015.09.009
Abstract from PubMed
PDF File

Progressive decline of glucocerebrosidase in aging and Parkinson's disease.
Rocha et al. 
Ann Clin Transl Neurol, 2015 • 23(6), Apr. 2, 2015, doi: 10.1002/acn3.177
Abstract from PubMed
PDF File

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain a-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.
Rocha et al. 
Antioxidants & Redox Signaling, 2015 • 23(6), doi: 10.1089/ars.2015.6307
Abstract from PubMed
PDF File

A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).
Smith et al.
PLoS One, 2015 • 10(3), Mar. 27, 2015, doi: 10.1371/journal.pone.0121072
Abstract from PubMed
PDF File

Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease
Cell Stem Cell, 2015 • 16, 269-274
Abstract
PDF File

Long-term health of dopaminergic neuron transplants in Parkinson's disease patients
Cell Reports, 2014, 7:1755-61, doi:10.1016/j.celrep.2014.05.027
Abstract
PDF File

Progressive axonal transport and synaptic protein changes correlate with behavioral and neurpathological abnormalities in the heterozygous Q175KI mouse model of Huntington's disease
Human Molecular Genetics, April 30, 2014, doi: 10.1093/hmg/ddu166
Abstract
PDF File

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
Neurobiology of Disease, 2014 • 62:381-386
Abstract
PDF File

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
Science Transl Med, July 4, 2012 • 4:52-64
Abstract
PDF File

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits.
Neurobiol Dis,Apr. 19, 2012 •47:258-67.
Abstract
PDF File

Viral and Inflammatory Triggers of Neurodegenerative Diseases.
Science Transl Med, Feb 15, 2012 • 4:121-3.
Abstract
PDF File

Mailman Research Center