In the News

Dr. Ole Isacson featured on Biorasi’s Few & Far Between podcast, discussing the integration of AI in neurological diseases.

Department of Defense – Congressionally Directed Medical Research Programs (CDMRP) 2023 Parkinson’s Research Highlights.

2023 Parkinson’s Highlight - CDMRP. Mechanisms of Specific Lipid-Induced Degeneration Causing Non-Motor Symptoms of Parkinson’s Disease.

Steppingstones: Four Milestones On The Path To Neurological Cell Therapy.

An update of our work for Parkinson's disease alongside our colleagues at Mass General Brigham.

Further coverage of our findings that neurons and glia have trouble with their lipid content in Parkinson’s disease.

Here’s the direct link to the open-access paper

Lipids redistribute between neurons and glia in Parkinson’s disease.

New Scientific Sense podcast featuring Ole Isacson, discussing novel findings related to neurodegenerative disease. Listen on Spotify.

https://podcast.scientificsense.net/820.

Drs. Schumacher, Isacson, Hallet, and Osborn

Drs. Schumacher, Isacson, Hallet, and Osborn

Coveted NIH Grant to Clinically Study Autologous Stem Cell Therapy for Parkinson’s Disease

Neuroregeneration Institute receives funding for clinical trials by NIH for autologous neurons in Parkinson's disease. 
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Researchers find that lipid accumulation in the brain may be an early sign of Parkinson's disease.

Researchers find that lipid accumulation in the brain may be an early sign of Parkinson's disease 
Read

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How the gene behind Huntington’s disease could be neutralized

How anti-sense treatment for Huntington's disease started at the Neuroregeneration Laboratories Read

Previously in the News

 

Cell therapy from iPSC works in Parkinson's preclinical models confirmed | Alzforum. Read

Health and Medicine: A new era in Parkinson's disease treatments. 
Read

Engelender and Isacson suggest new theory for how Parkinson's disease develops - ScienceDaily. Read

Fighting Parkinson's in the lab. Read

NPR interviews Dr. Isacson about Mohammed Ali's fight with Parkinson's disease. Listen

National Stem Cell Foundation and Michael J. Fox Foundation Partner to Support Parkinson's Cell Replacement Therapy. Read

MJFF Parkinson podcast with Dave Iverson and Ole Isacson 2016: The stem cells basics. Listen

Ole Isacson Lecture on Parkinson's disease in a Dish: Induced Pluripotent Stem Cell Models of Disease SFN Neurobiology of Disease Workshop graduate course. Watch

WMIF 2015 | Regeneration, Cell Therapy, and Neurocare: Products? Delivery? Watch

Nature Biotechnology reviews the use of iPSCs for drug discovery and modeling of familial Parkinson's disease in cell culture. Read

Ole Isacson - Keynote speech at Innovative Medicines Initiative (IMI) Stakeholder forum 2014. Watch

Long-term survival of dopamine neurons in patients: Encouraging news for future stem-cell based dopamine neuron transplant. Listen

Dr. Isacson Elected Fellow of The American Association for the Advancement of Science. Read

Dr. Isacson Presents Stem Cell Research at Vatican Conference in Rome. Read

Dr. Isacson Selected for Executive Scientific Advisory Board of the Michael J. Fox Foundation. Read

Getting Closer to a Stem Cell Therapy for Parkinson’s Disease. Read

Neuroregeneration Lab's Amyotrophic Lateral Sclerosis (ALS) Research Featured in New Video. Watch

Mitochondrial Energetics Energize Parkinson's Disease iPSC-derived Neural Study. Read

Personalized Medicine Closer to Reality. Read

PDiPS Consortium and Neuroregeneration Institute show cells from different patients have unique drug responses. Read

FRONTLINE: A Report on Parkinson's Disease
Update on PBS: June, 2012

Dr. Penny Hallett speaks about new PD research 
2010 Southeastern Parkinson Disease Conference, October 16, 2010. Watch

Dr. Isacson speaks at the 2010 Parkinson Action Network Morris K. Udall Awards Dinner 
Parkinson Action Network Official Site: Udall Dinner Highlights

Harvard Stem Cell Institute Monthly Update 
December 2009. Read

HSCI Highlights Stem Cell Sorting Work at the Neuroregeneration Lab. Read

NINDS GO Grant funding awarded for PDiPS Cell Line Research Consortium. Read

Interview with Dr. Isacson. Read

Cozzarelli Prize Awarded 
The Cozzarelli Prize recognizing recently published PNAS papers of outstanding scientific excellence and originality has been awarded to Wernig et al. 2008. This article is a shared collaborative work between the Harvard/McLean (Dr. Isacson's lab) and MIT (Dr. Jaenisch's lab). This is the first paper to show induction of stem cells from skin cells, then conversion to dopaminergic cells and successful functional testing in animal models of Parkinson’s disease.
Press Release from Eurekalert
Wernig et al. 2008 PDF File

FRONTLINE: A Report on Parkinson's Disease 
Coming soon to PBS; Early 2009Video Highlights

Summit on Stem Cell Research and New Clinical Trials 
Brain Repair Centre/Center for Neuroregeneration Research 2008:Press Release and Photo

Reprogrammed adult skin cells treat Parkinson's disease in animal model 
HarvardScience Online; April 10, 2008Article Link

Stem Cells from Skin Treat Brain Disease in Rats 
Reuters Online; April 7, 2008Article Link

Parkinson's Brain Cell Transplants Last for Years 
Reuters Online; April 6, 2008Article Link

Partnership is a Real No-Brainer; Dal-Harvard to work together on brain repair 
The Chronicle Herald; February 21, 2008Halifax Chronicle Herald, Feb. 21, 2008
Metro Newspaper, Feb. 21, 2008
Press Release 

Neuron Connections May Be Key to Stemming Parkinson's Disease 
McLean Hospital News; August 20, 2007Press Release 
PDF File of Article

Discovering the strengths and weaknesses of the Dopamine neuron: The role of G-substrate 
The Journal of Neuroscience; August 1, 2007Article Link

Development of new therapies for Parkinson’s disease (Interview with Ole Isacson) 
JoVE, Issue 3, May 2007Link to Video Article

Spurring Protein Breakdown in Brain Cells Halts Huntington’s Pathology 
The Harvard Focus Online; Published on March 9, 2007Article Link

Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells
Alzheimer Research Forum; March 8, 2007Article Link

Stem Cell Work Shows Promise and Risks
The Washington Post; Published on October 23, 2006Article Link
PDF File of Article

Stem cell research targets Parkinson's
The Atlanta Journal-Constitution; Published on October 17, 2006
Press Conference at the 36th Annual Society for Neuroscience Meeting, Atlanta, GAPDF File of Article
HCNR News Website

4th Cellular and Molecular Treatments Conference
Sept. 29-30, 2006McLean Hospital Press Conference Link 

Neuronal Stem Cells: A Long Road Ahead For Als, PD, And Glioblastoma Treatment
Neurology Today: Volume 6(14) 18 July 2006 p 15-16
PDF File of Article

The Promise and Pitfalls of Embryonic Stem Cells
September 22, 2005
Article Link

Fetal-cell Transplants Reverse Parkinson’s in Patients
June 10, 2005, Harvard Focus
Article Link

Clinical study results in Parkinson's patients may lead to development of future stem cell transplantation methodsMay 5, 2005 Michael J. Fox Foundation Press

Huntington's Defects Manifest Far from Damaged Brain Tissue
September 3, 2004, Harvard Focus
http://focus.hms.harvard.edu/2004/Sept3_2004/neurology.html
Huntington's disease multiple cell abnormalities and adaptive mechanisms Reuters Health InformationPDF file of article

HD gene product alters protein handling in patient's skin and brain, with complex toxic effects only in the most vulnerable brain cellsJuly 23, 2004, Press Release, EurekAlert!
http://www.eurekalert.org/pub_releases/2004-07/jws-eoh071904.php 
New study on Huntington's disease reveals pathology and new treatment options
July 30, 2004, McLean Hospital Press Release
http://www.mclean.harvard.edu/news/press/current.php?id=58
The Scientist recognizes Harvard/McLean Parkinson's Disease Udall Center's contribution on ES cells.
Embryonic Stem Cells WorkJune 21, 2004, The Scientist
http://www.the-scientist.com/yr2004/jun/hot_040621.html
PDF file of article

US Stem Cell Research LaggingSunday, May 23, 2004, The Boston Globe
Article from the Boston Globe
PDF file of article

Stem Cell work for Parkinson's Disease at the Neuroregeneration LabSunday, February 29, 2004, The Boston Globe
PDF file of Article from the Boston Globe

Harvard Wide Initiative for Stem Cell ResearchSunday, February 29, 2004, The Boston Globe
PDF file of Article from the Boston Globe

Professor Ole Isacson interviewed: Harvard's latest work on embryonic stem cells for Parkinson's disease
Friday, March 12, 2004, Grassroots Connection
Article from Grassroots Connection

Gene therapy used to treat patient with Parkinson's
Tuesday, August 19, 2003, The New York Times
Abstract from NY Times Archive
Article from NY Times

The production and use of cells as therapeutic agents in neurodegenerative diseasesIsacson O. Lancet Neurology 2003 Jul;2(7):417-24. 
Abstract from PubMed
Download PDF file

Enzyme Linked to Pathology of Parkinson's Disease Appears Two-faced. http://focus.hms.harvard.edu/2002/Nov8_2002/neurology.html

Stem Cell Hopes Double. http://www.nature.com/nsu/020617/020617-11.html